β-catenin在哺乳动物毛囊发育中作用机制的研究进展Research Progress on the Role of β-catenin in Development of Mammals Hair Follicle
姜怀志;
摘要(Abstract):
β-catenin是经典的Wnt信号通路关键性的下游效应器,在机体许多器官和组织的发育中发挥重要的调控作用。哺乳动物的毛囊是其机体具有自我修复和再生功能的器官之一,β-catenin是其周期性发育过程中众多调控因子之一。因此,对国内外β-catenin对哺乳动物毛囊调控的相关研究结果进行综述,为进一步揭示β-catenin对哺乳动物毛囊周期性发育作用机制提供相关依据。
关键词(KeyWords): 哺乳动物;毛囊;发育;β-catenin
基金项目(Foundation): 吉林省科技发展计划项目(20120802)
作者(Authors): 姜怀志;
DOI: 10.13326/j.jea.2015.0044
参考文献(References):
- [1]Nusslein-Volhard C,wieschaus E.Mutaions affecting segment number and polarity in Drosophila[J].Nature,1980,287(5785):795-801.
- [2]Mc Crea P D,Turck C W,Gumbiner B.A homolog of the armadillo protein in Drosophila(plakogiobin)associated with Ecadherin[J].Science,1991,254(5036):1359-1361.
- [3]韩涛,丁劲,王红阳.β-catenin信号分子的生物学功能及其在肝癌中的研究进展[J].中国生物工程杂志,2011,31(9):96-102.
- [4]Kohler E M,Chandra S H,Behrens J.Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal,desmoid and duodenal tumors[J].Hum Mol Genet,2009,18:213-226.
- [5]Igota S,Tosa M,Murakami M,et al.Identification and characterization of Wnt signaling pathway in keloid pathogenesis[J].Int J Med Sci,2013,10(4):344-354.
- [6]Stadeli R,Hoffmans R,Basler K.Transcription under the control of nuclear Arm/beta-catenin[J].Curr Biol,2006,16(10):378-385.
- [7]Xu W,Kimelman D.Mechanistic insights from structural studies of beta-catenin and its binding parners[J].Curr Biol,2007,120(19):3337-3344.
- [8]Weis E I,Nelson W J.Re-solving the cadherin-caenin-actin conundrum[J].J Biol Chem,2006,281(47):35593-35597.
- [9]Fan D,Hzake D,Zheng Y,et al.Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity[J].Biol Chem,2007,282(15):11221-11229.
- [10]Morin P J,Sparks A B,Korinek V,et al.Activation of betacatenin-Tcf signaling in colon cancer by mutation in beta-catenin or APC[J].Science,1997,275:1787-1790.
- [11]Bienz M.Beta-catenin:a pivot between cell adhesion and Wnt signaling[J].Curr Biol,2005,15(2):64-67.
- [12]Niemann C,Owens D M,Hulsken J,et al.Expression of Delta NLefl in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours[J].Development,2002,129(1):95-109.
- [13]Gat U,Das Gupta R,Degenstein L,et al.De novo hair follicle morphogenesis and hair tumors in mice expressing a truncatedβ-catenin in skin[J].Cell,1998,95(5):605-614.
- [14]Huelsken J,Vogel R,Erdmann B,et al.Beta-catenin controls hair follicle mophogenesis and cell differentiation in the skin[J].Mol Cell,2001,105(4):533-545.
- [15]仇文颖,徐园园,许增禄.β-连环蛋白对毛囊细胞增殖的调节作用[J].解剖学报,2006,37(6):660-664.
- [16]Wang L C,Liu Z F,Gambardella L,et al.Regular articles:conditional disruption of hedgehog signaling pathway defines its critical role in hair development and regeneration[J].J Jnvest Dermatol,2000,114(5):901-908.
- [17]张艺,施春英,杨恬.β-catenin在毛囊干细胞中转位表达与细胞增殖的关系[J].西北国防医学杂志,2008,29(3):180-182.
- [18]任志丹,郁枫,卢光.牦牛、藏山羊胚胎下颌不同类型毛囊形态发生及其β-catenin表达规律比较[J].黑龙江畜牧兽医,2011(5):12-15.
- [19]张艺,杨恬,樊红艳.β-catenin在大鼠毛囊损伤修复中表达的研究[J].创伤外科杂志,2004,6(6):448-450.
- [20]张艺,杨恬,樊红艳,等.β-连珠蛋白在人毛囊发育形成中的表达[J].西北国防医学杂志,2004,25(2):117-119.
- [21]王卓.幼龄水貂毛囊发育及皮肤中β-catenin和BMP2表达规律的研究[D].北京:中国农业科学院,2014.
- [22]吴瑜瑜.甘肃超细毛羊胎儿发育中后期毛囊形态发生中Wnt10b、β-catenin和FGF18基因表达的研究[D].兰州:甘肃农业大学,2013.
- [23]孔德清.内蒙古绒山羊胚胎毛囊形态发生及β-catenin表达规律的研究[D].西安:西北农林科技大学,2012.
- [24]谷博,孙丽敏,姜怀志.β-catenin基因在辽宁绒山羊皮肤毛囊中表达的研究[J].经济动物学报,2012,16(3):144-147.
- [25]王潇.BMP2/BMP4,β-catenin在绒山羊毛囊生长周期皮肤中表达及毛囊干细胞定位的研究[D].呼和浩特:内蒙古农业大学,2014.
- [26]马森.Wnt/β-catenin信号通路相关基因在绒山羊绒毛周期性再生及着色过程中的表达分析[D].西安:西北农林科技大学,2014.