陈明帅;徐超;宋兴超;刘学庆;邢秀梅;赵家平;

• 1:中国农业科学院特产研究所农业部特种经济动物遗传育种与繁殖重点实验室吉林省特种经济动物分子生物学省部共建国家重点实验室

摘要(Abstract)：

热休克蛋白(Heatshock proteins,HSP),是生物受到环境中物理、化学、生物、精神等刺激时产生应激反馈而合成的蛋白质。作为进化保守的蛋白家族之一,普遍存在于各种生物体中,并在生物体内发挥着重要的生理功能。HSP因具有丰富强大的分子伴侣、抗应激、调节细胞凋亡、抗氧化、参与机体免疫等生物学功能,决定了其广泛的用途。大量的试验表明,近年来HSP在相关领域的应用研究已获得了重要的突破与进展,特别是在疾病免疫和药物开发中的应用研究。文中在阐明HSP分子调控的基础上,综述了近年来热休克蛋白家族(HSP90、HSP70、HSP60和小分子HSP)在功能和应用方面的研究进展,为进一步完善对HSP的研究提供一定的参考。

关键词(KeyWords)： 热休克蛋白;分子伴侣;细胞凋亡;功能

Abstract:

Keywords:

基金项目(Foundation): 吉林省科技发展计划项目(20130206029NY);; 中国农业科学院科技创新工程项目(ASTIP-ISAPS01)

作者(Authors): 陈明帅;徐超;宋兴超;刘学庆;邢秀梅;赵家平;

DOI: 10.13326/j.jea.2016.1116

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