吕喆,于亚洲,胡桂学,赵哲

• 1:吉林农业大学动物科学技术学院
• 2:大连理工大学软件学院
• 3:吉林省通榆县动物检疫站

摘要(Abstract)：

西尼罗河病毒病是由西尼罗河病毒(West Nile Virus,WNV)引起的一种人畜共患传染病,病原是一种虫媒病毒,可导致西尼罗河热和致死性的西尼罗河脑炎。自发现以来,西尼罗河病毒病曾在世界上多个国家暴发,给畜牧业和人类生命安全造成了巨大的危害。我国目前尚无该病的发生,但是防治技术储备是必要的。本文对西尼罗河病毒病的流行病学、病原学、致病机制、临床症状和病理剖检变化、诊断方法和候选疗法进行综述,为西尼罗河病毒病的防控提供资料。

关键词(KeyWords)： 西尼罗河病毒病;西尼罗河病毒;研究进展

Abstract:

Keywords:

基金项目(Foundation): 国家科技支撑计划项目(2010BAD04B00)

作者(Author): 吕喆,于亚洲,胡桂学,赵哲

DOI: 10.13326/j.jea.2012.01.003

参考文献(References)：

• [1]方美玉,任瑞文,刘建伟,等.西尼罗病毒病研究进展[C]∥新发传染病防治学习研讨会论文集.广州:广东省预防兽医学专业委员会,2008:27-31.
• [2]Michael S Diamond.Progress on the development of therapeutics a-gainst West Nile virus[J].Antiviral Research,2009,83:215-216.
• [3]Vogt M R,Moesker B,Goudsmit J,et al.Human monoclonal an-tibodies induced by natural infection against West Nile Virus neu-tralize at a post-attachment step[J].Virol,2009,83:6494-6507.
• [4]Wang P,Dai J,Bai F,et al.Matrix metalloproteinase 9 facilitatesWest Nile virus entry into the brain[J].Virol,2008,82:8978-8985.
• [5]Verma S,Lo Y,Chapagain M,et al.West Nile virus infectionmodulates humanbrain microvascular endothelial cells tight junctionproteins and cell adhesion molecules:transmigration across the invitro blood-brain barrier[J].Virology,2009,385:425-433.
• [6]Dai J,Wang P,Bai F,et al.ICAM-1 participates in the entry ofWest Nile virus into the central nervous system[J].Virol,2008,82:4164-4168.
• [7]Siddharthan V,Wang H,Motter N E,et al.Persistent West NileVirus associated with a neurological sequela in hamsters identifiedbymotor unit number estimation[J].Virol,2009,83:4251-4261..
• [8]Dauphin G,Zientara S.West Nile virus:Recent trends in diagno-sis and vaccine development[J].Vaccine,2007,25:5563-5576.
• [9]Zhang W,Wu J,Li Y,et al.Rapid and accurate in vitro assaysfor detection of West Nile virus in blood and tissues[J].TransfusMed Rev,2009,23:146-154.
• [10]Padgett K A,Cahoon-Young B,Carney R,et al.Field and labo-ratory evaluation of diagnostic assays for detecting West Nile virusin oropharyngeal swabs from california wild birds[J].VectorBorne Zoonotic Dis,2006,6(2):183-191.
• [11]Beasley D W,Holbrook M R,Travassos Da Rosa A P,et al.Useof a recombinant envelope protein subunit antigen for specific sero-logical diagnosis of West Nile virus infection[J].Clin Microbiol,2004,42(6):2759-2765.
• [12]Ng C Y,Gu F,Phong W Y,et al.Construction and characteri-zation of a stable subgenomic dengue virus type 2 replicon systemfor antiviral compound and siRNA testing[J].Antiviral Res,2007,76:222-231.
• [13]Ben-Nathan D,Gershoni-Yahalom O,Samina I,et al.Usinghigh titer West Nile intravenous immunoglobulin from selected Is-raeli donors for treatment of West Nile virus infection[J].BMCInfect Dis,2009,9:18.
• [14]Deas T S,Bennett C J,Jones S A,et al.In vitro resistance se-lection and in vivo efficacy of morpholine oligomers against WestNile virus[J].Antimicrob Agents Chemother,2007,51:2470-2482.
• [15]Chang J,Wang L,Ma D,et al.Novel imino sugar derivativesdemonstrate potent antiviral activity against flaviviruses[J].An-timicrob Agents Chemother,2009,53:1501-1508.