动物抗菌肽抗病毒性质及其机制The Antiviral Properties and Mechanism of Animal Antimicrobial Peptides
韩彤彤,肖向红,徐艳春
摘要(Abstract):
简要综述了近年来有关抗菌肽抗病毒性质的研究动态、抗病毒机理及展望。
关键词(KeyWords): 抗菌肽;抗病毒;机理
基金项目(Foundation):
作者(Author): 韩彤彤,肖向红,徐艳春
DOI: 10.13326/j.jea.2006.03.015
参考文献(References):
- [1]Zasloff M.Antimicrobial peptides of multicellular organisms[J].Na-ture,2002,415:389-395.
- [2]崔艳红,黄现青.抗菌肽的抗菌机理研究进展[J].兽药与饲料添加剂,2005,10(3):14-16.
- [3]Nicolas P,Mor A.Peptides as weapons against microorganisms inthe chemical defense system of vertebrates[J].Annu Rev Microbi-ol,1995,49:277-304.
- [4]Wachinger M,Kleinschmidt A,Winder D,et al.Antimicrobialpeptides melittin and cecropin inhibit replication of human immun-odeficiency virus 1 by suppressing viral gene expression[J].Journalof General Virology,1998,79:731-740.
- [5]Gawronska B,Leuschner C,Enright F M,et al.Effects of a lyticpeptide conjugated to bHCG on ovarian cancer:studies in vitro andin vivo[J].Gynecol Oncol,2002,85:45-52.
- [6]Habermann E.Bee and wasp venoms[J].Science,1972,177:314-322.
- [7]Kreil G.Structure of melittin isolated from two species of honey bees[J].FEBS Lett,1973,33:241-244.
- [8]Blondelle S E,Houghten R A.Probing the relationships between thestructure and hemolytic activity of melittin with a complete set ofleucine substitution analogs[J].Pept Res,1991,4:12-18.
- [9]Werkmeister J A,Kirkpatrick A,McKenzei J A,et al.The effect ofsequence variations and structure on the cytolytic activity of melittinpeptides,Biochim[J].Biophys,1993,1 157:50-54.
- [10]Lee D G,Park J H,Shin S Y,et al.Design of novel analogue pep-tides with potent fungicidal but low hemolytic activity based on thececropin A-melittin hybrid structure[J].Biochem Mol Biol Int,1997,43:489-498.
- [11]Arrowood M J,Jaynes J M,Healey M C.In vitro activities of lyticpeptides against the sporozoites of Cryptosporidium parvum[J].Antimicrob Agents Chemother,1991,35:224-227.
- [12]Marcos J F,Beachy R N,Houghten R A,et al.Inhibition of plantvirus infection by melittin[J].Proceedings of the National Acade-my of Sciences,1995,92:12 466-12 469.
- [13]Baghian A,Jaynes J,Enright F.An amphipathic alpha-helical syn-thetic peptide analogue of melittin inhibits herpes simplex virus-1(HSV-1)-induced cell fusion and virus spread[J].Peptides,1997,18:177-183.
- [14]Boman H G.Peptide antibiotics and their role in innate immunity[J].Annual Review of Immunology,1995,13:61-92.
- [15]Zasloff M.Magainins,a class of antimicrobial peptides from Xeno-pus skin:isolation,characterization of two active forms,and par-tial cDNA sequences of a precursor[J].Proc Natl Acad Sci,1987,84:5 449-5 453.
- [16]Mariam E,Monta C,Dorothy L,et al.Caroline Attardo Genco.Antiviral effects of synthetic membrane-active peptides on HerpesSimplex Virus,Type 1[J].International of Antimicrobial Agents,1999,13:57-60.
- [17]Mor A,Nicolas P.Isolation and structure of a novel defensive pep-tides from frog skin[J].Eur J Biochem,1994,219:145-154.
- [18]Belaid A,Aouni M,Khelifa R,et al.In vitro antiviral activity ofdermaseptins against herpes simplex virus type 1[J].Journal ofmedical virology,2002,66:229-234.
- [19]Lorina C,Saidib H,Belaidc A,et al.The antimicrobial peptidedermaseptin S4 inhibits HIV-1 infectivity in vitro[J].Virology,2005,334:264-275.
- [20]Chinchar V G,Wang J,Murti G,et al.Inactivation of Frog Virus 3and channel catfish by esculentin-2P and ranatuerin-2P,two an-timicrobial peptide isolated from frog skin[J].Virology,2001,288:351-357.
- [21]Chinchar V G,Bryan L,Silphadaung U,et al.Inactivation ofviruses infecting ectothermic animals by amphibian and piscine an-timicrobial peptides[J].Virology,2004,323:268-275.
- [22]Ganz T,Selsted M E,Szklarek D,et al.Defensins.Natural pep-tide antibiotics of human neutrophils[J].J Clin Invest,1985,76:1 427-1 435.
- [23]Selsted M E,Harwig S S L,Ganz T,et al.Primary structures ofthree human neutrophil defensins[J].J Clin Invest,1985,76:1 436-1 439.
- [24]Daher K A,Selsted M E,Lehrer R I.Direct inactivation of virus byhuman granulocyte defensins[J].Journal of virology,1986,12:1 068-1 074.
- [25]Lehrer R I,Daher K,Ganz T,et al.Direct inactivation of virusesby MCP-1 and MCP-2,natural peptide antibiotics from rabbitleukocytes[J].J Virol,1985,54:467-472.
- [26]Albiol Matanic V C,Castilla V.Antiviral activity of antimicrobialcationic peptides against Junin virus and herpes simplex virus[J].International Journal of Antimicrobial Agents,2004,23:382-389.
- [27]Chang T L,Francois F,Mosoian A,et al.CAF-mediated HIV-1transcriptional inhibition is distinct from-αdefensin-1 HIV inhibi-tion[J].J Virol,2003,77:6 777-6 784.
- [28]Zhang L,Yu W,He T,et al.Contribution of human-αdefensin-1,-2,and-3 to the anti-HIV-1 activity of CD8 antiviral factor[J].Science,2002,298:995-1 000.
- [29]Lockey T D,Ourth D D.Formation of pores in Escherichia coli cellmembranes by a cecropin isolated from hemolymph of Heliothisvirescens larvae[J].European Journal of Biochemistry,1996,236(1):263-271.
- [30]Zerial A,Skerlavag B,Gennaro R,et al.Inactivation of herpessimplex virus by protein components of bovine neutrophil granules[J].Antiviral Res,1987,7:341-352.
- [31]Clark M A,Conway T M,Shorr R G L,et al.Identification andisolation of a mammalian protein which is antigenically and func-tionally related to the phospholipase A2 stimulatory peptide melit-tin[J].Journal of Biological Chemistry,1987,262:4 402-4 406.
- [32]牛国琴.空间稳定免疫脂质体体内过程及其对策的研究进展[J].国外医学药学分册,2002,29(5):301-306.
- [33]Sharma S V.Melittin-induced hyperactivation of phospholipase A2activity and calcium influx in ras-transformed cells[J].Oncogene,1993,8:939-947.
- [34]Fisher P J,Prendergast F G,Ehrhardt M R,et al.Calmodulin in-teracts with amphiphilic peptides composed of all d-amino acids[J].Nature,1994,368:651-653.
- [35]Gravitt K R,Ward N E,O’Brian C A.Inhibition of protein kinaseC by melittin:antagonism of binding interactions between melittinand the catalytic domain by active-site binding of MgATP[J].Bio-chemical Pharmacology,1994,47:425-427.
- [36]冯兴军,王建华,单安山.抗菌肽基因工程研究及其表达策略[J].中国生物工程杂志,2006,26(3):63-67.
- [37]Michael C J,Sonnevend A,Patel M,et al.A melittin-related pep-tide from the skin of the Japanese frog,Rana tagoi,with antimi-crobial and cytolytic properties[J].Biochemical and BiophysicalResearch communications,2003,306:496-500.