血管内皮生长因子(VEGF)及其受体在雌性动物繁殖上的研究进展Advances of VEGF Role and Its Receptors on the Reproduction of Female Animal
戢爽,姜怀志,张君正
摘要(Abstract):
血管内皮因子(VEGF)是一种由各种正常细胞和肿瘤细胞合成和分泌的一种糖蛋白。VEGF家族包括VEGF-A,VEGF-B,VEGF-C,VEGF-D,PGF 5个成员,VEGF有3种受体,即:Flt-1,Flt-4,Flk-1/KDR。VEGF与受体结合具有促进血管内皮细胞的增生和提高血管通透性的作用。VEGF及其受体在雌性动物卵巢上的卵泡、黄体正常发育与维持,子宫内膜的周期性变化及胚胎发育与附植等方面均具有重要作用。
关键词(KeyWords): 血管内皮生长因子;受体;雌性动物;繁殖
基金项目(Foundation): 吉林省科技厅项目(吉科合字20030210-2)
作者(Author): 戢爽,姜怀志,张君正
DOI: 10.13326/j.jea.2005.03.019
参考文献(References):
- [1]Sirois M G.VEGF effect on vascular permeability is mediated bysynthesis of platelet-activating factor[J].American Journal of Phys-iology,1997,272(6part2):2 746-2 756.
- [2]Ferrara N,Henzel W L.Pituitary follicular cells secrete a novelheparin-binding growth factor specific for vascular endothelial cell[J].Biochem Biophys Res Commun,1989(161):851-858.
- [3]Carmeliet P,Ferreira V,Breier C,et al.Abnormal blood vesseldevelopment and lethality in embryos lacking a single VEGF allele[J].Nature,1996,380:435.
- [4]Bussolino F,Mantovani A,Persico G.Molecular mechanisms ofblood vessel formation[J].TIBS,1997,22:251.
- [5]Paavonen K,Horelli-Kitnen N,Chelov D,et al.Novel human vas-cular endothelial growth factor-genes VEGF-B and VEGF-C lo-calized to chromosome 11q13 and 4q34,respectively[J].Circulaton,1996,93(6):1 079.
- [6]Joukov V,Kaipainen A,Jeltsch M,et al.Vascular endothelialgrowth factors VEGF-B and VEGF-C[J].J Cell Physiol,1997,173:211.
- [7]Shibuya M.Role of VEGF-FLT receptor system in normal and tu-mor angiogenesis[J].Adv Cancer Res,1995,67:281.
- [8]Brown L F,Detmar M,Claffey K,et al.Vasclular permeability fac-tor/vascular endothelial growth factor:A multifunctional angio-genic cytokine[J].Exs,1997,79:233.
- [9]Kaipainen A,Korhonen J,Mustonen T,et al.Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothe-lium during development[J].Proc Natl Acad Sci USA,1995,92:3 566.
- [10]Kendall R L,Wang G,Thomas K A.Identification of a natural sol-uble form of the vascular endothelial growth factor receptor FLT-1,and its heterodimerization weth KDR[J].Biochem Biophys ResCommun,1996,226(2):324.
- [11]Neufeld Gcohen T,Stela G,et al.Vascular en-dothelial growthfactor(VEGF)and its receptors[J].FASEB J,1999,13:9-12.
- [12]Fournier E,Blaikie P,Olivior R,et al.Role of tyrosine residuesand protein interaction domains of SHEadaptor in VEGF receptor 3signalling[J].Oncongene,1999,18:507-514.
- [13]Ferrara N,Carver-Moore H,Chen M,et al.Heterozygous embry-onic lethality induced by targeted inactivation of the VEGF gene[J].Nature,1996(380):439-442.
- [14]Beck L,D amore P A.Vascular development,cellular and molec-ular regulation[J].FASEB J,1997,11:356-373.
- [15]Murohara T,horow itz J R silver M,et al.Vascular endothelialgrowth factor/vascular permeadility factor enhances vascles perme-adility bia nitric oxide and prostacychlin[J].Circulation,1998,97(1):99-107.
- [16]Feng D,nagy J A,Hipp J,et al.reinterpretation of endothelialcell gaps induced by vasoactivy mediators in gu ineapig mouse andrat:many are transcellular pores[J].Circlation,1998,97(1):99-107.
- [17]Hayashi T abe K,Suzuki H,et al.rapid inductin of vascular en-dothelial growth factor gene expression after transient middle cere-bral artery occlsion in rast stroke[J].Endocrinol,1997,8(10):2 039-2 044.
- [18]van derzee R,murohara T,et al.vascular endothelial growth fac-tor/vascular permeadility factor augments itric oxide release fromquiescent rabbit and human vascular endothelial[J].Circulation,1997,95(4):1 030-1 037.
- [19]Stoufer R,Lmartinez-Cheqer J C,Molskness T A,et al.Regulationand action of angioenic factors in the primate ovary[J].Arch MedRes,2001,32:567-575.
- [20]Geva E,Jjjafe R B.Role of vascular endothelial groth factor in o-varian physiology and pathology[J].Fertil Steril,2000,74:429-438.
- [21]李庆雷,王红梅,祝诚,等.血管内皮生长因子在妊娠及产后大鼠卵巢中的表达[J].中国科学C辑,2002,32(2):131-137.
- [22]Otane N,Minami S,Yamoto M,et al.The vascular endothelialgrowth factor/fms-like tyrosine kinase system in human ovaryduring the menstral cycle and pregnancy[J].Jj Clin EndocrinolMmetab,1999,84:3 845-3 851.
- [23]Neulen J,Raczek S,Pogorzelski M,et al.Secretion of vascularendothelial growth factor/vascular permeability factor from humanluteinized granlosa cells is human chorionic gonadotrophin depen-dent[J].Mol Hum Reprod,1998,4:203-206.
- [24]Levitas E,Chamoun D,Udoff L C,et al.Periovuulatory and inter-leuukin-1 beta-dependent up-regulation of intraovarian vascularendothelial growth factor(VEGF)in the rat:Potential role forVEGF in the promotion of periovulatory angiogenesis and vascularpermeability[J].J Soc Gynecol Investig,2000,7:51-60.
- [25]Ferrara N,Chen H,Dacis-Smyth T,et al.Vasclar endothelialgrowth factor is essential for corpus luteum angiogenesis[J].Nat ed,1998,4:336-340.
- [26]邵龙江,祝诚.雌性生殖系统中的血管生成[J].科学通报,2001,46(5):355-358.
- [27]Meduri G,Bausero P,Perrot-Applanat M.Expression of vascularendothelial growth factor receptors in the human endometrium:Modulation during the menstrual cycle[J].Biol Reprod,2000,62:439-447.
- [28]Sandberg T,Casslen B,Gstavasson B,et al.Human endothelialcell migration is stimulated by rokinase plasminogen activa-tor.Plasminogen activator inhibitor complex released from endome-trial stromal cells stimulated with transforming growth factor betal:possible mechanism for paracrine stimulation of endomtrial angio-genesis[J].Biol Reprod,1998,59:759-767.
- [29]Medure G,Bausero P,Perrot-Applanat M.Exptression of vascularengothelial growth factor receptors in the human endometrim:mod-ulatin during the mehstral cycle[J].Biol Reprod,2000,62(2):439-447.
- [30]Lessey B A.The role of the endometrium during embryo implan-tatin[J].Hm Reprod,2000,6(suppl):39-50.
- [31]Carmeliet P,Ferreira V,Breier G,etal.Heterozygous embryoniclethality induced by targeted inactivation of the VEGFallele[J].Nature,1996,380:435-439.
- [32]Ferrara N,Carver-Moore K,Chen H,etal.Heterozygous embryon-ic lethality induced by targeted inactivation of the VEGF gene[J].Nature,1996,380:439-442.
- [33]张键,铁国梁,段恩奎,等.纤维粘连蛋白质与白血病抑制因子对小鼠胚泡基质金属蛋白酶基因表达的影响[J].科学通报,2001,46(5):401-404.
- [34]蔡理全,曹宇静,段恩奎,等.整合素αVβ3在小鼠胚胎植入中的作用[J].科学通报,2000,45(15):1 639-1 643.
- [35]邵龙江,王红梅,祝诚,等.围植入期大鼠子宫中血管上皮因子的表达与血管生成[J].科学通报,2001,46(5):397-400.
- [36]Lessey B A.The role of the endometrum during embryo implanta-tion[J].Hum Reprod,2000,6(suppl):39-50.
- [37]Sherer D M,Abulafia O.Angioenesis during implantation.and pla-cental and early embryonic development[J].Placenta,2001,22:1-13.
- [38]Smith S K.Aniogenesis and implanatation[J].Hum Reprod,2000,6(suppl):59-66.
- [39]Fraser H M,Lunn S F.Angiogenesis and its control in the femalereproductive system[J].Br Med Bull,2000,56:787-797.
- [40]张晶.王莉.段恩奎,等.血管内皮生长因子在小鼠胚胎植入“窗口”的表达和功能[J].科学通报,2000,45:2 535-2 539.
- [41]Winther H,Ahmed A,Dantzer V.Immujohistochemical localizationof vascular endothelial growth factor(VEGF)and its two specifictrceptors.Flt-1and KDR.in the porcine placenta and non-prenant ters[J].Placenta,1999,20:35-43.