白秀娟,刘宗岳,李玉梅,李秋芳,林宁,马丽娜

• 1:吉林农业大学中药材学院
• 2:中国农业科学院特产研究所
• 3:吉林大学畜牧学院
• 4:双鸭山市饶河县畜牧局

摘要(Abstract)：

自咬症是世界范围内养殖的毛皮兽广泛流行的疾病之一,其危害主要表现在皮张质量的降低。目前对该症的发病机理和检测方法报道很少,因此早期诊断和淘汰患病个体成为防止该病发生的主要措施。从2007年起,课题组开始利用标记辅助选择或基因辅助选择等措施,寻找与水貂自咬症相关的候选基因和分子标记,共筛选出6对特异性分子标记,并发现3个候选基因的7个突变位点与自咬症的发生显著相关。文中对课题组近5年研究成果作一综述,为阐明自咬症的发病机理给予新的提示与参考。

关键词(KeyWords)： 水貂;自咬症;分子标记;候选基因

Abstract:

Keywords:

基金项目(Foundation): 国家留学基金委项目

作者(Author): 白秀娟,刘宗岳,李玉梅,李秋芳,林宁,马丽娜

DOI: 10.13326/j.jea.2013.03.004

参考文献(References)：

• [1]王维恩.蓝狐自咬症的诊治[J].青海畜牧兽医杂志,1999,29(4):32.
• [2]倪有煌,李毓义.兽医内科学[M].北京:中国农业出版社,1996:444-445.
• [3]高宏伟,陈维岩,马振凯.水貂自咬症研究概况[J].毛皮动物饲养,1995(3):41-43.
• [4]孙得发,贾康胜,王建华,等.毛皮动物自咬症与大脑神经细胞脂质过氧化关系初步分析[J].经济动物学报,2006,10(4):242-247.
• [5]Cynthia M,Kahn M A.The Merck Veterinary Manual[M].9th ed.N J,USA:published byMerck&Co Inc Whitehouse Station,2005.
• [6]Mason G J.Stereotypy and welfare in mink[J].J Anim Sci,1992,70(suppl):158.
• [7]Mason G J.Age and context affect the stereotypies of caged mink[J].Behaviour,1993,127:191-229.
• [8]Mason G J.Tail-biting in mink(Mustela vison)is influenced by age at removal from the mother[J].Animal Welfare,1995,3:305-311.
• [9]Hansen C P B.Stereotypies in ranch mink:The effect of genes,litter size and neighbors[J].Behavioural Processes,1993,29:165-177.
• [10]Hansen C P B,Jeppesen L L.The swimming activity of farm mink(Mustela vison)and its relation to stereotypies[J].Acta Agric Scand,2001,51:71-76.
• [11]李秀敏,沈为红,张志挺,等.毛皮动物自咬病的防治措施[J].当代畜牧,2003(7):22.
• [12]Novak M A.Self-injurious behavior in rhesus monkeys:new insights into its etiology,physiology,and treatment[J].Am J Primato,2003,59(1):3-19.
• [13]Tiefenbacher S,Novak M A,Marinus LM,et al.Meyer Altered hypothalamic-pituitary-Adrenocor-tical function in rhesus monkeys(Macaca mulatta)with self-injurious behavior[J].Psychoeuroendoc-rinology,2004,29(4):501-515.
• [14]Suhail Kasim,Innah HA.Self-Biting Induced by Activation of LType Calcium Channels in Mice[J].Developmental Neuroscience,2003,25:20-25.
• [15]Breese G R,Knapp D J,Criswell H E,et al.The neonate-6-hydroxydopamine-lesioned rat:a model for clinical neuroscience and neurobiological principles[J].Brain Res,2005,48(1):57-73.
• [16]侯卓成,杨宁.家禽主要组织相容性复合体的研究进展[J].遗传,2002,24(1):72-76.
• [17]张婷.辽东湾斑海豹MHC-DQB基因的遗传多样性分析[D].青岛:山东农业大学,2010.
• [18]林宁.水貂自咬行为及其相关基因关系的研究[D].哈尔滨:东北农业大学,2008.
• [19]李秋芳.水貂自咬症遗传病因的SCAR分子标记分析[J].西北农业学报,2010,19(4):28-33.
• [20]马丽娜.水貂自咬症分子诊断的初步研究[D].长春:吉林农业大学,2008.
• [21]李玉梅.水貂体重、皮长性状相关基因研究及自咬症病因分子遗传分析[D].哈尔滨:东北农业大学,2008.
• [22]刘宗岳.水貂主要生产性状的遗传分析及自咬症的分子诊断[D].哈尔滨:东北农业大学,2009.
• [23]Liu Zongyue,Ning Fangyong,Bai Xiujuan.Rapid detection for self-biting disease of mink by Specific sequence-Characterized Amplified Regions[J].J Forest Res,2011,22(1):123-126.
• [24]Chirwa S,Aduonum A,Pizarro J,et a1.Dopamineme DA1 signaling couples growth associated protein-43 and long-term potential ion in guinea pig hippocampus[J].Brain Res Bull,2005,64(5):433-440.
• [25]Sivam S P.Dopamine,serotonin and tachykinin in selfinjurious behavior[J].Life Sci,1996,58:2367-2375.
• [26]Lara-Lemus A,Perez de-Lamoram M,Mendez-France J,et al.Effects of REM sleep deprivation on the d-amphetamine-induced self-mutilating behavior[J].Brain Res,1997,770(1/2):60-64.
• [27]Breese G R,Criswell H E,Mueller R A.Evidence that lack of brain dopamine during development can increase the susceptibility for aggression and self-injurious behavior by influencing D1-dopamine receptor function[J].Prog Neuro-psychopharmacol Biol Psychiatry,1990,14:S65-S80.
• [28]Sarkar R,Shin D H,Liu H,et al.Patterns of status epileptieus-indueed neuronal injuryduring development and long term consequenees[J].Neurosei,1998,18:8382-8393.
• [29]Portera C,Hedreen L C,Priee D L,et al.Evidence for apoptotic cell death in Huntington diease and exeitototic animal models[J].Neurosei,1995,15:3775-3787.
• [30]Sakhi S,Bruee A,Sun N,et al.P53 induction is associated with neuronal damage in the central nervous system[J].Proc Natl Acad Sei USA,1994,91:7525-7529.
• [31]Saiki RK,Gelfand DH,Stoffel S,et al.Primer-directed enzymatic amplification of DNAwith a thermostable DNA polymerase[J].Science,1998,239:487-491.
• [32]Gillardon F,Wickert H,Zimmermann M.Up-regulation of bax and down regulation of bcl-2 is associatedwith kanic-induced apoptosis in mouse brain[J].Neurosei Lett,1995,192:85-88.
• [33]Faherty C J,Xanthoudakis S,Smeyne R J.Caspase-3 dependent neuronal death in the hippocampus following kanic acid treatment[J].Brain ResMol Brain Res,1999,70:159-163.
• [34]Henshall D C,Chen J,Simon R P.Involvement of caspase-3 like protease in the mechanism of cell death following focally evoked limbic seizures[J].Neuroehem,2000,74:1215-1223.
• [35]Day M J.Expression of major histocompatability complex class II molecules by dermal inflammatory cells,epidermal Langerhans cells and keratinocytes in canine dermatological disease[J].Journal of Comparative Pathology,1996,115:317-326.
• [36]Stemmer B L,Arlian LG,MorganMS,etal.Characterization of antigen presenting cells and T-cells in progressing scabietic skin lesions[J].Veterinary Parasitology,1996,67:247-258.
• [37]JacksonHA,Olivry T,BergetF,et al.Immunopathology of vesicular cutaneous lupus erythematosus in the rough collie and Shetland sheepdog:a canine homologue of subacute cutaneous lupus erythematosus in humans[J].Veterinary Dermatology,2004,15:230-239.
• [38]Affolter VK,Moore P F.Localised and disseminated histiocytic sarcoma of dendritic cell origin in dogs[J].Veterinary Pathology,2002,39:74-83.
• [39]Maillard J C.Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis[J].GenetSel Evol,2003,35:193-200.