2022 01 v.26 62-66
免疫佐剂的研究进展
基金项目(Foundation):
吉林省教育厅“十三五”科学技术项目(JJKH20190945KJ);;
国家重点研发计划课题(2016YFD0501002)
邮箱(Email):
guixue1964@126.com;wangbs5215616@sohu.com;
DOI:
10.13326/j.jea.2020.1540
中文作者单位:
吉林农业大学动物医学院;长春中医药大学附属临床医院;
摘要(Abstract):
佐剂通过调节、增强机体的免疫应答而提高预防和治疗性疫苗的免疫效力。研究开发低毒、高效的免疫佐剂，对疫苗特别是新型疫苗的研发具有重要意义。文中对近年来一些常规佐剂和新型佐剂进行简要综述，为免疫佐剂研制提供有益参考。
关键词(KeyWords):
免疫佐剂;;疫苗;;研究进展
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参考文献
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[33] Kobari S,Kusakabe T,Momota M,et al.IL-33 is essential for adjuvant effect of hydroxypropyl-β-cyclodexrin on the protective intranasal influenza vaccination[J].Frontiers in Immunology,2020,11:360-371.
[34] Wang Z B,Xu J.Better adjuvants for better vaccines:progress in adjuvant delivery systems,modifications,and adjuvant-antigen codelivery[J].Vaccines,2020,8(1):128-137.
[35] Yan D,Wei Y Q,Guo H C,et al.The application of virus-like particles as vaccines and biological vehicles[J].Applied Microbiology and Biotechnology,2015,99(24):10415-10432.
[36] Sominskaya I,Skrastina D,Dislers A,et al.Construction and immunological evaluation of multivalent hepatitis B virus (HBV) core virus-like particles carrying HBV and HCV epitopes[J].Clinical and Vaccine Immunology,2010,17(6):1027-1033.
[37] Lee S J,Park H J,Ko H L,et al.Evaluation of glycoprotein E subunit and live attenuated varicella-zoster virus vaccines formulated with a single-strand RNA-based adjuvant[J].Immun Inflamm Dis,2020,8(2):216-227.
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[43] Zhang C,Zhou J F,Liu Z X,et al.Comparison of immunoadjuvant activities of four bursal peptides combined with H9N2 avian influenza virus vaccine[J].Journal of Veterinary Science,2018,19(6):817-826.
[2] Glenny A T,Pope C G,Waddington H,et al.Immunological notes.XVII-XXIV[J].Journal of Pathology and Bacteriology,1926,29(1):31-40.
[3] Hassett K J,Cousins M C,Rabia L A,et al.Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization[J].European Journal of Pharmaceutics and Biopharmaceutics,2013,85(2):279-286.
[4] Traquina P,Morandi M,Contorni M,et al.MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in Primates[J].Journal of Infectious Diseases,1996,174(6):1168-1175.
[5] Hassett K J,Vance D J,Jain N K,et al.Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid a adjuvants[J].Journal of Pharmaceutical Sciences,2015,104(2):627-639.
[6] Didierlaurent A M,Morel S,Lockman L,et al.AS04,an aluminum salt-and TLR4 agonist-based adjuvant system,induces a transient localized innate immune response leading to enhanced adaptive immunity[J].Journal of Immunology,2009,183(10):6186-6197.
[7] O'Hagan D T.Vaccine adjuvants:preparation methods and research protocols[M].[s.l.]:Humana Press,2000:49-64.
[8] O'Hagan D T,Ott G S,Nest G V,et al.The history of MF59? adjuvant:a Phoenix that arose from the ashes[J].Expert Review of Vaccines,2013,12(1):13-30.
[9] Gar?on N,van Mechelen M.Recent clinical experience with vaccines using MPL-and QS-21-containing adjuvant systems[J].Expert Review of Vaccines,2011,10(4):471-486.
[10] Hoang H H,Wang P C,Chen S C.Interleukin 34 serves as a novel molecular adjuvant against Nocardia seriolae infection in largemouth bass (Micropterus salmoides)[J].Vaccines,2020,8(2):151-175.
[11] Thorne A H,Malo K N,Wong A J,et al.Adjuvant screen identifies synthetic DNA-encoding Flt3L and CD80 immunotherapeutics as candidates for enhancing anti-tumor T cell responses[J].Frontiers in Immunology,2020,11:327-340.
[12] Schnurr M,Orban M,Robson N C,et al.ISCOMATRIX adjuvant induces efficient cross-presentation of tumor antigen by dendritic cells via rapid cytosolic antigen delivery and processing via tripeptidyl peptidase Ⅱ[J].Journal of Immunology,2009,182(3):1253-1259.
[13] Jacobs C,Duewell P,Heckelsmiller K,et al.An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma[J].International Journal of Cancer,2011,128(4):897-907.
[14] Magedans Y V,Yendo A C,Costa F D,et al.Foamy matters:an update on Quillaja saponins and their use as immunoadjuvants[J].Future Medicinal Chemistry,2019,11(12):1485-1499.
[15] Al-Zeer M A,Al-Younes H M,Lauster D,et al.Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins[J].Autophagy,2013,9(1):50-62.
[16] Zhou B Q,Song J,Wang M,et al.BSA-bioinspired gold nanorods loaded with immunoadjuvant for the treatment of melanoma by combined photothermal therapy and immunotherapy[J].Nanoscale,2018,10(46):21640-21647.
[17] Tao W Q,Ziemer K S,Gill H S.Gold nanoparticle-M2e conjugate coformulated with CpG induces protective immunity against influenza A virus[J].Nanomedicine,2014,9(2):237-251.
[18] Xu L G,Liu Y,Chen Z Y,et al.Surface-engineered gold nanorods:promising DNA vaccine adjuvant for HIV-1 treatment[J].Nano Letters,2012,12(4):2003-2012.
[19] Chen Y S,Hung Y C,Lin W H,et al.Assessment of gold nanoparticles as a size-dependent vaccine carrier for enhancing the antibody response against synthetic foot-and-mouth disease virus peptide[J].Nanotechnology,2010,21(19):195101-195108.
[20] Yamada H,Urata C,Aoyama Y,et al.Preparation of colloidal mesoporous silica nanoparticles with different diameters and their unique degradation behavior in static aqueous systems[J].Chemistry of Materials,2012,24(8):1462-1471.
[21] Abbaraju P L,Jambhrunkar M,Yang Y N,et al.Asymmetric mesoporous silica nanoparticles as potent and safe immunoadjuvants provoke high immune responses[J].Chemical Communications,2018,54(16):2020-2023.
[22] AbdelAllah N H,Gaber Y,Rashed M E,et al.Alginate-coated chitosan nanoparticles act as effective adjuvant for hepatitis A vaccine in mice[J].Int J Biol Macromol,2020,152:904-912.
[23] Zhao J,Li J Q,Jiang Z L,et al.Chitosan,N,N,N-trimethyl chitosan (TMC) and 2-hydroxypropyltrimethyl ammonium chloride chitosan (HTCC):The potential immune adjuvants and nano carriers[J].International Journal of Biological Macromolecules,2020,154:339-348.
[24] El-Sissi A F,Mohamed F H,Danial N M,et al.Chitosan and chitosan nanoparticles as adjuvant in local Rift Valley Fever inactivated vaccine[J].3 Biotech,2020,10(3):88-98.
[25] Li S,Yang Y L,Lin X,et al.Biocompatible cationic solid lipid nanoparticles as adjuvants effectively improve humoral and T cell immune response of foot and mouth disease vaccines[J].Vaccine,2020,38(11):2478-2486.
[26] Tsai M H,Chuang C C,Chen C C,et al.Nanoparticles assembled from fucoidan and trimethylchitosan as Anthrax vaccine adjuvant:In vitro and in vivo efficacy in comparison to CpG[J].Carbohydrate Polymers,2020,236:116041-116081.
[27] Huang L,Ikejiri A,Shimizu Y,et al.Immunoadjuvant activity of crude lectin extracted from Momordica charantia seed[J].Journal of Veterinary Medical Science,2008,70(5):533-535.
[28] Chandrashekar P M,Venkatesh Y P.Fructans from aged garlic extract produce a delayed immunoadjuvant response to ovalbumin antigen in BALB/c mice[J].Immunopharmacology and Immunotoxicology,2012,34(1):174-180.
[29] Gautam M,Saha S,Sarang B N,et al.Immunomodulatory activity of Asparagus racemosus on systemic Th1/Th2 immunity:Implications for immunoadjuvant potential[J].Journal of Ethnopharmacology,2009,121(2):241-247.
[30] Turmagambetova A S,Alexyuk M S,Bogoyavlenskiy A P,et al.Effect of the nanocapsulated adjuvant sapomax on the expression of some immune response genes[J].Archives of Virology,2020,165(6):1445-1451.
[31] Song Y C,Huang H C,Chang C Y,et al.A Potential herbal adjuvant combined with a peptide-based vaccine acts against HPV-related tumors through enhancing effector and memory T-cell immune responses[J].Frontiers in Immunology,2020,11:62-76.
[32] Ma L B,Xu B Y,Huang M,et al.Effects of recombinant Agrocybe aegerita lectin as an immunoadjuvant on immune responses[J].Immunopharmacology and Immunotoxicology,2018,40(1):6-12.
[33] Kobari S,Kusakabe T,Momota M,et al.IL-33 is essential for adjuvant effect of hydroxypropyl-β-cyclodexrin on the protective intranasal influenza vaccination[J].Frontiers in Immunology,2020,11:360-371.
[34] Wang Z B,Xu J.Better adjuvants for better vaccines:progress in adjuvant delivery systems,modifications,and adjuvant-antigen codelivery[J].Vaccines,2020,8(1):128-137.
[35] Yan D,Wei Y Q,Guo H C,et al.The application of virus-like particles as vaccines and biological vehicles[J].Applied Microbiology and Biotechnology,2015,99(24):10415-10432.
[36] Sominskaya I,Skrastina D,Dislers A,et al.Construction and immunological evaluation of multivalent hepatitis B virus (HBV) core virus-like particles carrying HBV and HCV epitopes[J].Clinical and Vaccine Immunology,2010,17(6):1027-1033.
[37] Lee S J,Park H J,Ko H L,et al.Evaluation of glycoprotein E subunit and live attenuated varicella-zoster virus vaccines formulated with a single-strand RNA-based adjuvant[J].Immun Inflamm Dis,2020,8(2):216-227.
[38] Hanagata N.CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers,infectious diseases,and allergies[J].International Journal of Nanomedicine,2017,12:515-531.
[39] Ito S,Hirobe S,Kawakita T,et al.Characteristic of K3 (CpG-ODN) as a transcutaneous vaccine formulation adjuvant[J].Pharmaceutics,2020,12(3):E267-283.
[40] Hu Y L,Tang L,Zhu Z Y,et al.A novel TLR7 agonist as adjuvant to stimulate high quality HBsAg-specific immune responses in an HBV mouse model[J].Journal of Translational Medicine,2020,18(1):112-123.
[41] Gupta N,Regar H,Verma V K,et al.Receptor-ligand based molecular interaction to discover adjuvant for immune cell TLRs to develop next-generation vaccine[J].Int J Biol Macromol,2020,152:535-545.
[42] Miller S M,Cybulski V,Whitacre M,et al.Novel lipidated imidazoquinoline TLR7/8 adjuvants elicit influenza-specific Th1 immune responses and protect against heterologous H3N2 influenza challenge in mice[J].Frontiers in Immunology,2020,11:406-423.
[43] Zhang C,Zhou J F,Liu Z X,et al.Comparison of immunoadjuvant activities of four bursal peptides combined with H9N2 avian influenza virus vaccine[J].Journal of Veterinary Science,2018,19(6):817-826.
基本信息:
DOI：10.13326/j.jea.2020.1540
中图分类号:S859.797
引用信息:
[1]于得静,张添琪,孟凡茹等.免疫佐剂的研究进展[J].经济动物学报,2022,26(01):62-66.DOI:10.13326/j.jea.2020.1540.
基金信息:
吉林省教育厅“十三五”科学技术项目(JJKH20190945KJ);; 国家重点研发计划课题(2016YFD0501002)
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