| 590 | 0 | 15 |
| 下载次数 | 被引频次 | 阅读次数 |
近年来，我国宠物的数量持续增加，其中犬、猫的占比最高。宠物被视为重要的家庭成员，其健康和福利的受关注度越来越高。犬、猫常见的健康问题包括胃肠道疾病、免疫力低下、肥胖、衰老和慢性肾病等。肠道健康和菌群状况是影响犬、猫身体机能的重要因素。近年来，益生菌在犬、猫饲粮中的应用不断发展，益生菌能通过调节肠道菌群平衡和代谢影响犬、猫多个系统的健康。对益生菌的作用机制及益生菌在犬、猫上应用的研究现状进行综述，以期为宠物益生菌产品的开发和应用提供理论依据，对潜在的研究方向提出建议。
Abstract：In recent years, the number of pets in China has continued to increase, with the highest percentage of dogs and cats. Pets are increasingly regarded as family members, and their health and welfare are becoming a significant area of interest. The most common health issues observed in dogs and cats include gastrointestinal disorders, immune compromise, obesity, ageing, chronic kidney disease and other chronic metabolic issues. The gut health and flora balance of dogs and cats are significant factors that influence their physiological functions. In recent years, there has been notable advances in the application of probiotics in veterinary medicine, particularly in the treatment of canine and feline patients. Probiotics have been shown to exert a profound impact on the overall health and well-being of these animals by influencing the equilibrium of the intestinal flora and metabolic processes. The article primarily reviewed the mechanisms of the actions of probiotics and their application in dogs and cats. We tend to offer theoretical foundations for the development and application guidance of pet probiotic products and shed light on potential avenues for further research.
[1]张庶冉，曹晨，刘月明，等.宠物食品安全性评估中的风险及应对策略[J].中国饲料，2024(1):125-129.
[2] Matchock R L. Pet ownership and physical health[J]. Current Opinion in Psychiatry, 2015, 28(5):386-392.
[3] Tan J S Q, Fung W, Tan B S W, et al. Association between pet ownership and physical activity and mental health during the COVID-19"circuit breaker"in Singapore[J]. One Health,2021, 13:100343.
[4]包书芳，罗佩先，陈燕妮.宠物肠道健康与营养调控研究[J].兽医导刊，2021(5):91-92.
[5] Hill J H, Round J L. Snapshot:Microbiota effects on host physiology[J]. 2021, 184(10):2796-2796.
[6] Paone P, Cani P D. Mucus barrier, mucins and gut microbiota:The expected slimy partners?[J]. Gut, 2020, 69(12):2232-2243.
[7] Lee W J, Hase K. Gut microbiota-generated metabolites in animal health and disease[J]. Nature Chemical Biology, 2014,10(6):416-424.
[8] Schmitz S, Suchodolski J. Understanding the canine intestinal microbiota and its modification by pro-, pre-and synbioticswhat is the evidence?[J]. Veterinary Medicine and Science,2016, 2(2):71-94.
[9] Alessandri G, Milani C, Mancabelli L, et al. Deciphering the bifidobacterial populations within the canine and feline gut microbiota[J]. Applied and Environmental Microbiology, 2020,86(7):e02875.
[10] Lee D, Goh T W, Kang M G, et al. Perspectives and advances in probiotics and the gut microbiome in companion animals[J].Journal of Animal Science and Technology, 2022, 64(2):197-217.
[11] Pilla R, Suchodolski J. The gut microbiome of dogs and cats,and the influence of diet[J]. Veterinary Clinics of North America:Small Animal Practice, 2021, 51(3):605-621.
[12] Kim S Y, Adachi Y. Biological and genetic classification of canine intestinal lactic acid bacteria and bifidobacteria[J].Microbiology&Immunology, 2007, 51(10):919-928.
[13] Handl S, Dowd S, Garcia-Mazcorro J, et al. Massive parallel16S r RNA gene pyrosequencing reveals highly diverse fecal bacterial and fungal communities in healthy dogs and cats[J].FEMS Microbiology Ecology, 2011, 76(2):301-310.
[14] Clauss M, Kleffner H, Kienzle E. Carnivorous mammals:Nutrient digestibility and energy evaluation[J]. Zoo Biology,2010, 29(6):687-704.
[15] Deng P, Swanson K S. Gut microbiota of humans, dogs and cats:Current knowledge and future opportunities and challenges[J]. The British Journal of Nutrition, 2015, 113(Sl):6-17.
[16] Manjarres Z, Calvo M, Pacheco R. Regulation of pain perception by microbiota in parkinson disease[J]. Pharmacological Reviews, 2023, 76(1):7-36.
[17] Damborg P, S?rensen A H, Guardabassi L. Monitoring of antimicrobial resistance in healthy dogs:First report of canine ampicillin-resistant Enterococcus faecium clonal complex 17[J].Veterinary Microbiology, 2008, 132(1/2):190-196.
[18] Ding S, Yan W, Ma Y, et al. The impact of probiotics on gut health via alternation of immune status of monogastric animals[J]. Animal Nutrition, 2021, 7(1):24-30.
[19] Koh A, Vadder F D, Kovatcheva-Datchary P, et al. From dietary fiber to host physiology:Short-chain fatty acids as key bacterial metabolites[J]. Cell, 2016, 165(6):1332-1345.
[20] Collins S L, Stine J, Bisanz J, et al. Bile acids and the gut microbiota:Metabolic interactions and impacts on disease[J].Nature Reviews Microbiology, 2023, 21(4):236-247.
[21] Hill C, Guarner F, Reid G, et al. Expert consensus document:The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic[J]. Nature Reviews Gastroenterology&Hepatology, 2014, 11(8):506-514.
[22] Ioannou A, Berkhout M D, Geerlings S Y, et al. Akkermansia muciniphila:Biology, microbial ecology, host interactions and therapeutic potential[J]. Nature Reviews Microbiology, 2025, 23:162-177.
[23] Sanders M E, Merenstein D J, Reid G, et al. Probiotics and prebiotics in intestinal health and disease:From biology to the clinic[J]. Nature Reviews Gastroenterology&Hepatology, 2019, 16(10):605-616.
[24] Button J E, Cosetta C M, Reens A L, et al. Precision modulation of dysbiotic adult microbiomes with a human-milk-derived synbiotic reshapes gut microbial composition and metabolites[J]. Cell Host&Microbe, 2023, 31(9):1523-1538.
[25] Bastos T S, Souza C M M, Kaelle G C B, et al. Diet supplemented with Saccharomyces cerevisiae from different fermentation media modulates the faecal microbiota and the intestinal fermentative products in dogs[J]. Journal of Animal Physiology&Animal Nutrition, 2023, 107(S1):30-40.
[26] Silva B C, Jung L R C, Sandes S H C, et al. In vitro assessment of functional properties of lactic acid bacteria isolated from faecal microbiota of healthy dogs for potential use as probiotics[J]. Beneficial Microbes, 2013, 4(3):267-275.
[27] Schmitz S S. Value of probiotics in canine and feline gastroenterology[J]. The Veterinary Clinics of North America:Small Animal Practice, 2021, 51(1):171-217.
[28] Suchodolski J S. Diagnosis and interpretation of intestinal dysbiosis in dogs and cats[J]. The Veterinary Journal,2016, 215:30-37.
[29] Jergens A, Simpson K. Inflammatory bowel disease in veterinary medicine[J]. Front Biosci(Elite Ed), 2012, 4(4):1404-1419.
[30] Schauf S, Fuente G D L, Newbold C J, et al. Effect of dietary fat to starch content on fecal microbiota composition and activity in dogs1[J]. Journal of Animal Science, 2018,96(9):3684-3698.
[31] Minamoto Y, Minamoto T, Isaiah A, et al. Fecal shortchain fatty acid concentrations and dysbiosis in dogs with chronic enteropathy[J]. Journal of Veterinary Internal Medicine, 2019, 33(4):1608-1618.
[32] Mcatee R, Schmid S M, Tolbert M K, et al. Effect of esomeprazole with and without a probiotic on fecal dysbiosis, intestinal inflammation, and fecal short-chain fatty acid concentrations in healthy dogs[J]. Journal of Veterinary Internal Medicine, 2023, 37(6):2109-2118.
[33] Fang C, Cheng J Y, Jia W, et al. Akkermansia muciniphila ameliorates alcoholic liver disease in experimental mice by regulating serum metabolism and improving gut dysbiosis[J].Metabolites, 2023, 13(10):1057.
[34] Liu Q, Yu Z, Tian F, et al. Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier[J].Microbial Cell Factories, 2020, 19(1):23.
[35] Zyrek A A, Cichon C, Helms S, et al. Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair[J]. Cellular Microbiology, 2007, 9(3):804-816.
[36] Yan F, Cao H W, Cover T L, et al. Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell survival and growth[J]. Gastroenterology, 2007, 132(2):562-575.
[37] Yan F, Polk D B. Probiotics and probiotic-derived functional factors-mechanistic insights into applications for intestinal homeostasis[J]. Frontiers in Immunology, 2020, 11:1428.
[38] Hutchins A P, Diego D, Diego M S. The IL-10/STAT3-mediated anti-inflammatory response:Recent developments and future challenges[J]. Briefings in Functional Genomics,2013(6):489-498.
[39] Yousefi B, Eslami M, Ghasemian A, et al. Probiotics importance and their immunomodulatory properties[J]. Journal of Cellular Physiology, 2019, 234(6):8008-8018.
[40] Maldonado G, Carolina C, Silvia I, et al. Beneficial effects of probiotic consumption on the immune system[J]. Annals of Nutrition and Metabolism, 2019, 74(2):115-124.
[41] You J L, Dong H L, Mann E R, et al. Probiotic modulation of dendritic cell function is influenced by ageing[J]. Immunobiology, 2014, 219(2):138-148.
[42] Konieczna P, Ferstl R, Ziegler M, et al. Immunomodulation by Bifidobacterium infantis 35624 in the murine Lamina propria requires retinoic acid-dependent and independent mechanisms[J]. PLoS One, 2013, 8(5):e62617.
[43] de Vos W D, Tilg H, Van Hul M, et al. Gut microbiome and health:Mechanistic insights[J]. Gut, 2022, 71(5):1020-1032.
[44] Allen A P, Dinan T G, Clarke G, et al. A psychology of the human brain-gut-microbiome axis[J]. Social and Personality Psychology Compass, 2017, 11(4):e12309.
[45] Soca?a K, Doboszewska U, Szopa A, et al. The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders[J]. Pharmacological Research, 2021, 172:105840.
[46] Fan Z C, Bian Z W, Huang H C, et al. Dietary strategies for relieving stress in pet dogs and cats[J]. Antioxidants, 2023,12(3):545.
[47] Dinan T G, Stilling R M, Stanton C, et al. Collective unconscious:How gut microbes shape human behavior[J]. Journal of Psychiatric Research, 2015, 63:1-9.
[48] Reardon S N. Gut-brain link grabs neuroscientists[J]. Nature, 2014, 515(7526):175-177.
[49] Mayer E A, Nance K, Chen S. The gut-brain axis[J]. Annual Review of Medicine, 2022, 27(73):439-453.
[50] Salleh R M, Kuan G, Aziz M N A, et al. Effects of probiotics on anxiety, stress, mood and fitness of badminton players[J].Nutrients, 2021, 13(6):1783.
[51] Le Morvan de Sequeira C, Hengstberger C, Enck P, et al.Effect of probiotics on psychiatric symptoms and central nervous system functions in human health and disease:A systematic review and meta-analysis[J]. Nutrients, 2022, 14(3):621.
[52] Bercik P, Denou E, Collins J, et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice[J]. Gastroenterology, 2011, 141(2):599-609.
[53] Bravo J, Forsythe P, Chew M V, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(38):16050-16055.
[54] Messaoudi M, Lalonde R, Violle N, et al. Assessment of psychotropic-like properties of a probiotic formulation(Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)in rats and human subjects[J]. British Journal of Nutrition, 2010, 105(5):755-764.
[55] Benton D, Williams C, Brown A. Impact of consuming a milk drink containing a probiotic on mood and cognition[J].European Journal of Clinical Nutrition, 2007, 61(3):355-361.
[56] Biagi E, Franceschi C, Rampelli S, et al. Gut microbiota and extreme longevity[J]. Current Biology, 2016, 26(11):1480-1485.
[57] Smith P M, Howitt M R, Panikov N, et al. The microbial metabolites, short-chain fatty acids, regulate colonic treg cell homeostasis[J]. Science, 2013, 341(6145):569-573.
[58] Kim C H, Jeongho P, Myunghoo K. Gut microbiota-derived short-chain fatty acids, T cells, and inflammation[J]. Immune Network, 2014, 14(6):277-288.
[59] Matsumoto M, Kurihara S, Kibe R, et al. Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production[J]. PLoS One, 2011, 6(8):e23652.
[60] Satoh T, Murata M, Iwabuchi N, et al. Effect of bifidobacterium breve B-3 on skin photoaging induced by chronic UV irradiation in mice[J]. Beneficial Microbes, 2015, 6(4):497-504.
[61] Kim H M, Lee D E, Park S D, et al. Oral administration of Lactobacillus plantarum HY7714 protects hairless mouse against ultraviolet b-induced photoaging[J]. Journal of Microbiology and Biotechnology, 2014, 24(11):1583-1591.
[62] Ritz E. Intestinal-renal syndrome:Mirage or reality?[J].Blood Purification, 2011, 31(1/2/3):70-76.
[63] Liu X Y, Wang X R, Zhang P P, et al. Intestinal homeostasis in the gut-lung-kidney axis:A prospective therapeutic target in immune-related chronic kidney diseases[J]. Frontiers in Immunology, 2023, 14:1266792.
[64]张筱烨，师帅帅.基于“肠—肾轴”理论肾脏病与肠道菌群关系研究进展[J].长治医学院学报，2022, 36(6):469-474.
[65] Amini Khiabani S, Asgharzadeh M, Samadi Kafil H. Chronic kidney disease and gut microbiota[J]. Heliyon, 2023, 9(8):e18991.
[66] Ranganathan N, Friedman E A, Tam P, et al. Probiotic dietary supplementation in patients with stage 3 and 4 chronic kidney disease:A 6-month pilot scale trial in Canada[J].Current Medical Research and Opinion, 2009, 25(8):1919-1930.
[67] Li H B, Xu M L, Xu X D, et al. Faecalibacterium prausnitzii attenuates CKD via butyrate-renal GPR43 axis[J]. Circulation Research, 2022, 131(9):120-134.
[68] Lopes R D C S O, Balbino K P, Jorge M D P, et al. Modulation of intestinal microbiota, control of nitrogen products and inflammation by pre/probiotics in chronic kidney disease:A systematic review[J]. Nutrición Hospitalaria, 2018:35(3):722-730.
[69] Brandl K, Kumar V, Eckmann L. Gut-liver axis at the frontier of host-microbial interactions[J]. American Journal of Physiology Gastrointestinal and Liver Physiology, 2017, 312(5):413-419.
[70] Wang J, Wang Y, Zhang X, et al. Gut microbial dysbiosis is associated with altered hepatic functions and serum metabolites in chronic hepatitis B patients[J]. Frontiers in Microbiology, 2017, 8:2222.
[71] Aly A R M, Adel A R, El-Gendy A O, et al. Gut microbiome alterations in patients with stage 4 hepatitis C[J]. Gut Pathogens, 2016, 8(1):42.
[72] Dubinkina V B, Tyakht A V, Odintsova V Y, et al. Links of gut microbiota composition with alcohol dependence syndrome and alcoholic liver disease[J]. Microbiome, 2017,5(1):141.
[73] Mohamad Nor M H, Ayob N, Mokhtar N M, et al. The effect of probiotics(MCP?BCMC?strains)on hepatic steatosis,small intestinal mucosal immune function, and intestinal barrier in patients with non-alcoholic fatty liver disease[J]. Nutrients, 2021, 13(9):3192.
[74] Wong W S, Wong L H, Chim M L, et al. Treatment of nonalcoholic steatohepatitis with probiotics:A proof-of-concept study[J]. Annals of Hepatology, 2013, 12(2):256-262.
[75] Duseja A, Acharya S K, Mehta M, et al. High potency multistrain probiotic improves liver histology in non-alcoholic fatty liver disease(NAFLD):A randomised, double-blind,proof of concept study[J]. BMJ Open Gastroenterology,2019, 6(1):e000315.
[76] Rudenko P, Vatnikov Y, Sachivkina N, et al. Search for promising strains of probiotic microbiota isolated from different biotopes of healthy cats for use in the control of surgical infections[J]. Pathogens, 2021, 10(6):667.
[77] Grze?kowiak?，Endo A, Beasley S, et al. Microbiota and probiotics in canine and feline welfare[J]. Anaerobe, 2015,34:14-23.
[78] Fernández L, Martínez R, Pérez M, et al. Characterization of Lactobacillus rhamnosus MP01 and Lactobacillus plantarum MP02 and assessment of their potential for the prevention of gastrointestinal infections in an experimental canine model[J]. Frontiers in Microbiology, 2019, 10:1117.
[79] Delucchi L, Fraga M, Zunino P. Effect of the probiotic Lactobacillus murinus LbP2 on clinical parameters of dogs with distemper-associated diarrhea[J]. Canadian Journal of Veterinary Research, 2017, 81(2):118-121.
[80] Marsella R. Evaluation of Lactobacillus rhamnosus strain GG for the prevention of atopic dermatitis in dogs[J]. American Journal of Veterinary Research, 2009, 70(6):735-740.
[81] Kumar S, Pattanaik A K, Sharma S, et al. Comparative assessment of canine-origin Lactobacillus johnsonii CPN23 and dairy-origin Lactobacillus acidophillus NCDC 15 for nutrient digestibility, faecal fermentative metabolites and selected gut health indices in dogs[J]. Journal of Nutritional Science,2017, 6:e38.
[82] Kumar S, Pattanaik A K, Sharma S, et al. Species-specific probiotic Lactobacillus johnsonii CPN23 supplementation modulates blood biochemical profile and erythrocytic antioxidant indices in Labrador dogs[J]. The Indian Journal of Animal Sciences, 2016, 86(8):918-924.
[83] Kumar S, Pattanaik A K, Sharma S, et al. Probiotic potential of a Lactobacillus bacterium of canine faecal-origin and its impact on select gut health indices and immune response of dogs[J]. Probiotics and Antimicrobial Proteins, 2017, 9(3):262-277.
[84] StrompfováV, Kuba?ováI, LaukováA. Health benefits observed after probiotic Lactobacillus fermentum CCM 7421 application in dogs[J]. Applied Microbiology and Biotechnology, 2017, 101(16):6309-6319.
[85] StrompfováV, MarciňákováM, SimonováM, et al. Application of potential probiotic Lactobacillus fermentum AD1 strain in healthy dogs[J]. Anaerobe, 2006, 12(2):75-79.
[86] StrompfováV, LaukováA, Gancar?íkováS. Effectivity of freeze-dried form of Lactobacillus fermentum AD1-CCM7421in dogs[J]. Folia Microbiologica, 2012, 57(4):347-350.
[87] Han B, Liang S K, Sun J T, et al. The effect of Lactobacillus plantarum on the fecal microbiota, short chain fatty acids,odorous substances, and blood biochemical indices of cats[J].Microorganisms, 2024, 12(1):91.
[88] Xu H Y, Huang W Q, Hou Q C, et al. Oral administration of compound probiotics improved canine feed intake, weight gain, immunity and intestinal microbiota[J]. Frontiers in Immunology, 2019, 10:666.
[89] Tang Y, Saris P E J. Viable intestinal passage of a canine jejunal commensal strain Lactobacillus acidophilus LAB20 in dogs[J]. Current Microbiology, 2014, 69(4):467-473.
[90] Baillon M L A, Marshall-Jones Z V, Butterwick R F. Effects of probiotic Lactobacillus acidophilus strain DSM13241 in healthy adult dogs[J]. American Journal of Veterinary Research, 2004, 65(3):338-343.
[91]田其真，唐晨晨，沈丹晴，等.唾液乳酸杆菌TCSL1对幼犬生长性能、血液学与血清生化指标及肠道健康的影响[J].中国畜牧兽医，2020, 47(11):3757-3766.
[92] Fusi E, Rizzi R, Polli M, et al. Effects of Lactobacillus acidophilus D2/CSL(CECT 4529)supplementation on healthy cat performance[J]. Veterinary Record Open, 2019, 6(1):e000368.
[93] StrompfováV, Pogány SimonováM, Gancar?íkováS, et al.Effect of Bifidobacterium animalis B/12 administration in healthy dogs[J]. Anaerobe, 2014, 28:37-43.
[94] O'Mahony D, Murphy S, Boileau T, et al. Bifidobacterium animalis AHC7 protects against pathogen-induced NF-κB activation in vivo[J]. BMC Immunology, 2010, 11:63.
[95] Kelley R L, Minikhiem D, Kiely B, et al. Clinical benefits of probiotic canine-derived Bifidobacterium animalis strain AHC7 in dogs with acute idiopathic diarrhea[J]. Veterinary Therapeutics, 2009, 10(3):121-130.
[96] Park H E, Kim Y J, Kim M, et al. Effects of queso blanco cheese containing Bifidobacterium longum KACC 91563 on fecal microbiota, metabolite and serum cytokine in healthy beagle dogs[J]. Anaerobe, 2020, 64:102234.
[97]王诚，丁博群，董桂红，等.复合益生菌制剂对宠物犬猫机体免疫力的影响[J].甘肃畜牧兽医，2023, 53(5):93-96.
[98] Arora K, Green M, Prakash S. The microbiome and alzheimer's disease:Potential and limitations of prebiotic, synbiotic, and probiotic formulations[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8:537847.
[99]刘静，朱道仙，陆江.肥胖犬粪便菌群移植对犬体况指数、血脂指标及肠道菌群的影响[J].黑龙江畜牧兽医，2020(22):147-151.
[100] Vazquez-Mendoza P, Elghandour M M M, Alaba P A, et al. Antimicrobial and bactericidal impacts of Bacillus amyloliquefaciens CECT 5940 on fecal shedding of pathogenic bacteria in dairy calves and adult dogs[J]. Microbial Pathogenesis, 2018, 114:458-463.
[101]杜莉，李群，吴德华，等.低聚木糖和纳豆芽孢杆菌对幼犬血液指标的影响[J].湖北农业科学，2009, 48(2):413-415.
[102] StrompfováV, Kuba?ováI，??erbováJ, et al. Oral administration of bacteriocin-producing and non-producing strains of Enterococcus faecium in dogs[J]. Applied microbiology and biotechnology, 2019, 103(12):4953-4965.
[103] Veir J K, Knorr R, Cavadini C, et al. Effect of supplementation with Enterococcus faecium(SF68)on immune functions in cats[J]. Veterinary Therapeutics, 2007, 8(4):229-238.
[104] Fenimore A, Lappin M R. Evaluation of metronidazole with and without Enterococcus faecium SF68 in shelter dogs with diarrhea[J]. Topics in Companion Animal Medicine,2017, 32(3):100-103.
[105] Lappin M R, Veir J K, Satyaraj E, et al. Pilot study to evaluate the effect of oral supplementation of Enterococcus faecium SF68 on cats with latent feline herpesvirus 1[J]. Journal of Feline Medicine&Surgery, 2009, 11(8):650-654.
[106] Lucena R, Novales M, Blanco B, et al. Effect of probiotic Enterococcus faecium SF68 on liver function in healthy dogs[J].Journal of Veterinary Internal Medicine, 2019, 33(6):2628-2634.
[107] Lucena R, Olmedilla A B, Blanco B, et al. Effect of Enterococcus faecium SF68 on serum cobalamin and folate concentrations in healthy dogs[J]. Journal of Small Animal Practice, 2018, 59(7):438-443.
[108] Benyacoub J, Czarnecki-Maulden G, Cavadini C, et al.Supplementation of food with Enterococcus faecium(SF68)stimulates immune functions in young dogs[J]. Journal of Nutrition, 2003, 133(4):1158-1162.
[109] Vahjen W, M?nner K. The effect of a probiotic Enterococcus faecium product in diets of healthy dogs on bacteriological counts of Salmonella spp. Campylobacter spp. and Clostridium spp. in faeces[J]. Archiv Für Tierernhrung, 2003, 57(3):229-233.
[110] D'Angelo S, Fracassi F, Bresciani F,et al. Effect of Saccharomyces boulardii in dog with chronic enteropathies:Double-blinded, placebo-controlled study[J]. Veterinary Record, 2018, 182(9):258.
[111] Bampidis V, Azimonti G, Bastos M D L, et al. Safety and efficacy of a feed additive consisting of Saccharomyces cerevisiae DSM 34246(Canobios-BL)for cats and dogs(ACEL pharma s.r.l.)[J]. EFSA Journal, 2024, 22(5):e8802.
[112] de Oliveira M L F, Risolia L W, Ernandes M C, et al. Effects of Saccharomyces cerevisiae cell wall addition on feed digestibility, fecal fermentation and microbiota and immunological parameters in adult cats[J]. BMC Veterinary Research, 2021, 17(1):351.
[113] Li Y F, Ali I, Lei Z Q, et al. Effect of a multistrain probiotic on feline gut health through the fecal microbiota and its metabolite SCFAs[J]. Metabolites, 2023, 13(2):228.
[114]徐春晗，徐凤宇，许祺珺.犬用益生菌研究进展[J].中国兽药杂志，2018, 52(8):80-85.
[115]陈斌，姜博文，段卫帅，等.复合益生菌和酶制剂对猫生长、血清指标、营养物质表观消化率及粪便菌群的影响[J].饲料工业，2023, 44(10):105-112.
[116] Hoon L S, Eun K J, Mi-La C. Immunological pathogenesis of inflammatory bowel disease[J]. Intestinal Research,2018, 16(1):26-42.
[117] Davenport M, Poles J, Leung J M, et al. Metabolic alterations to the mucosal microbiota in inflammatory bowel disease[J]. Inflammatory Bowel Diseases, 2014, 20(4):723-731.
[118] Suchodolski J S, Dowd S E, Wilke V, et al. 16S rRNA gene pyrosequencing reveals bacterial dysbiosis in the duodenum of dogs with idiopathic inflammatory bowel disease[J].PLoS One, 2012, 7(6):e39333.
[119] Inness V L, McCartney A L, Khoo C, et al. Molecular characterisation of the gut microflora of healthy and inflammatory bowel disease cats using fluorescence in situ hybridisation with special reference to Desulfovibrio spp.[J]. Journal of Animal Physiology and Animal Nutrition, 2007, 91(1/2):48-53.
[120] Janeczko S, Atwater D, Bogel E, et al. The relationship of mucosal bacteria to duodenal histopathology, cytokine mRNA, and clinical disease activity in cats with inflammatory bowel disease[J]. Veterinary Microbiology, 2008, 128(1/2):178-193.
[121] Sunvold G, Hussein H S, Fahey G C, et al. In vitro fermentation of cellulose, beet pulp, Citrus pulp, and Citrus pectin using fecal inoculum from cats, dogs, horses, humans,and pigs and ruminal fluid from cattle[J]. Journal of Animal Science, 1995, 73(12):3639-3648.
[122] Craven M, Egan C E, Dowd S E, et al. Inflammation drives dysbiosis and bacterial invasion in murine models of ileal Crohn's disease[J]. PLoS One, 2012, 7(7):e41594.
[123] White R, Atherly T, Guard B, et al. Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease[J]. Gut Microbes, 2017, 8(5):451-466.
[124] Zhang M, Mo R, Li M,ale t. Comparison of the effects of enzymolysis seaweed powder and Saccharomyces boulardii on intestinal health and microbiota composition in kittens[J].Metabolites, 2023, 13.
[125]周其琛.预防宠物犬、猫肥胖症和糖尿病的新方法[J].今日畜牧兽医，2018, 34(2):28-29.
[126] Ma X L, Brinker E, Graff E C, et al. Whole-genome shotgun metagenomic sequencing reveals distinct gut microbiome signatures of obese cats[J]. Microbiology Spectrum,2022, 10(3):e0083722.
[127] Lu X, Jing Y, Li Y, et al. The differential modulatory effects of Eurotium cristatum on the gut microbiota of obese dogs and mice are associated with improvements in metabolic disturbances[J]. Food&Function, 2021, 12(24):12812-12825.
[128] Alonge S, Aiudi G G, Lacalandra G M, et al. Pre-and probiotics to increase the immune power of colostrum in dogs[J].Frontiers in Veterinary Science, 2020, 7:570414.
[129] Chen G H, Zhou S Q, Chen Q, et al. Tryptophan-5-HT pathway disorder was uncovered in the olfactory bulb of a depression mice model by metabolomic analysis[J]. Frontiers in Molecular Neuroscience, 2022, 15:965697.
[130] Steenbergen L, Sellaro R, van Hemert S, et al. A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood[J]. Brain, Behavior,and Immunity, 2015, 48:258-264.
[131] Wang W C, Yan F F, Hu J Y, et al. Supplementation of Bacillus subtilis based probiotic reduces heat stress-related behaviors and inflammatory response in broiler chickens 1[J].Journal of Animal Science, 2018, 96(5):1654-1666.
[132] Lalonde R, Strazielle C. Probiotic effects on anxiety-like behavior in animal models[J]. Reviews in the Neurosciences, 2022, 33(6):691-701.
[133] Puurunen J, Tiira K, Vapalahti K, et al. Fearful dogs have increased plasma glutamine and gamma-glutamyl glutamine[J].Scientific Reports, 2018, 8(1):15976.
[134] Meineri G, Martello E, Atuahene D, et al. Effects of Saccharomyces boulardii supplementation on nutritional status,fecal parameters, microbiota, and mycobiota in breeding adult dogs[J]. Veterinary Sciences, 2022, 9(8):389.
[135] Masuoka H, Shimada K, Kiyosue-Yasuda T, et al. Transition of the intestinal microbiota of cats with age[J]. PLoS One, 2017, 12(8):e0181739.
[136] Masuoka H, Shimada K, Kiyosue-Yasuda T, et al. Transition of the intestinal microbiota of dogs with age[J]. Bioscience of Microbiota Food&Health, 2017, 36(1):27-31.
[137] Hong Y K, An S, Lee Y H, et al. Potential anti-ageing effects of probiotic-derived conditioned media on human skin cells[J]. Acta Pharmaceutica, 2022, 72(3):359-374.
[138] Bartges J W. Chronic kidney disease in dogs and cats[J].Veterinary Clinics of North America:Small Animal Practice, 2012, 42(4):669-692.
[139] Lippi I, Perondi F, Ceccherini G, et al. Effects of probiotic VSL#3 on glomerular filtration rate in dogs affected by chronic kidney disease:A pilot study[J]. The Canadian veterinary journal, 2017, 58(12):1301-1305.
[140] Palmquist R. A preliminary clincial evaluation of kibow biotics，?a probiotic agent, on feline azotemia[J]. Journal of the American Holistic Veterinary Medical Association,2006, 24:23-27.
[141] Lidbury J A, Suchodolski J S. New advances in the diagnosis of canine and feline liver and pancreatic disease[J]. Veterinary Journal, 2016, 215:87-95.
[142] Adler C J, Malik R, Browne G V, et al. Diet may influence the oral microbiome composition in cats[J]. Microbiome,2016, 4(1):23.
[143] Harris S, Croft J, O'Flynn C, et al. A pyrosequencing investigation of differences in the feline subgingival microbiota in health, gingivitis and mild periodontitis[J]. PLoS One, 2015, 10(11):e0136986.
[144] Hobi S, B?czkowski P M, Mueller R, et al. Malassezia dermatitis in dogs and cats[J]. The Veterinary Journal, 2024,304:106084.
[145]韩瑨，吴燕婷，万嗣宝，等.发酵乳杆菌B44益生性能的体外评价[J].上海大学学报（自然科学版），2021, 27(6):1162-1170.
[146] Zhang M R, Cui Y Y, Mei X Y, et al. Effect of dietary composite probiotic supplementation on the microbiota of different oral sites in cats[J]. Veterinary Sciences, 2024, 11(8):351.
[147] M?kinen V M, M?yr?A, Munukka E. Improving the health of teeth in cats and dogs with live probiotic bacteria[J].Journal of Cosmetics, Dermatological Sciences and Applications, 2019, 9(4):275-283.
[148] Jacobi C A, Schulz C, Malfertheiner P. Treating critically ill patients with probiotics:Beneficial or dangerous?[J].Gut Pathogens, 2011, 3(1):2.
[149] Kochan P, Chmielarczyk A, Szymaniak L, et al. Lactobacillus rhamnosus administration causes sepsis in a cardiosurgical patient:Is the time right to revise probiotic safety guidelines?[J]. Clinical Microbiology and Infection, 2011, 17(10):1589-1592.
[150]陈淋淋，谭紫凝，马红霞，等.双组分系统调控细菌毒力和耐药性及其抑制剂研究进展[J].经济动物学报，2023, 27(3):220-226.
[151]郑琳，魏炳栋，滑峰.缓释包被饲用抗生素替代品在畜禽生产中的研究进展[J].经济动物学报，2024, 28(2):86-95.
[152] Grzeskowiak L, Collado M C, Beasley S, et al. Pathogen exclusion properties of canine probiotics are influenced by the growth media and physical treatments simulating industrial processes[J]. Journal of Applied Microbiology, 2014,116(5):1308-1314.
[153] Kanasugi H, Hasegawa T, Goto Y, et al. Single administration of enterococcal preparation(FK-23)augments nonspecific immune responses in healthy dogs[J]. Annals of Work Exposures and Health, 1997, 19(11/12):655-659.
[154] Grzeskowiak L, Isolauri E, Salminen S, et al. Manufacturing process influences properties of probiotic bacteria[J].British Journal of Nutrition, 2011, 105(6):887-894.
[155]宋阳，沈维军，万发春，等.日粮因素对瘤胃微生物多样性影响及调控的研究进展[J].经济动物学报，2023, 27(4):290-296.
[156]李虹晔，王春凤，杨桂连.益生菌在维护宠物健康及疾病防治中的应用及作用研究进展[J].吉林农业大学学报，2023, 45(5):513-522.
[157] Gu Q Z, Yin Y, Yan X J, et al. Encapsulation of multiple probiotics, synbiotics, or nutrabiotics for improved health effects:A review[J]. Advances in Colloid and Interface Science, 2022, 309:102781.
[158] Centurion F, Basit A W, Liu J, et al. Nanoencapsulation for probiotic delivery[J]. ACS Nano, 2021, 15(12):18653-18660.
基本信息:
DOI：10.13326/j.jea.2025.2051
中图分类号:S852.6
引用信息:
[1]伍元晟,何泫臻,严浩然等.犬、猫益生菌的研究进展和应用现状[J].经济动物学报,2025,29(01):48-61.DOI:10.13326/j.jea.2025.2051.
基金信息:
广州市基础与应用基础研究项目（2023A04J0117）